FOLLICULAR DENDRITIC CELL PROMINENCE
Grade 1
Grade 3
This tool has been funded and produced by Recordati. All images have been provided by an international
panel of expert pathologists.
The concept, functionality and expert guidance found within this tool has
also
been developed with the support of expert pathologists.
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Follicular dendritic cell (FDC) prominence: Grade 3
This secondary follicle shows depletion of B-cells and a prominent proliferation of FDCs. The proliferation is very obvious when performing a CD21 immunostain.
Abbreviations
FDCs, follicular dendritic cells; H&E, hematoxylin and eosin.
This tool has been funded and produced by Recordati. All images have been provided by an international panel of expert pathologists. The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.
EXPERT GUIDANCE
Follicular dendritic cell (FDC) prominence: Grade 1
FDCs are present in primary and secondary B-cell follicles and play an important role in the antigen presentation to maturing B-cells. They form a network with their arborizing process. In this secondary germinal center there are very sparse follicular dendritic cells. They are characterised by 1 or 2 large round vesicular nuclei with a solitary central nucleolus. The dendritic process can be illustrated by immunohistochemistry against CD21, CD23, CD35 or podoplanin.
Abbreviations
FDCs, follicular dendritic cells; H&E, hematoxylin and eosin.
This tool has been funded and produced by Recordati. All images have been provided by an international panel of expert pathologists. The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.
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