Grade 2-3 regressed GCs are considered diagnostic. Please see below for examples supported by written guidance from a member of our expert panel.
Abbreviations
GCs, germinal centres.
This tool has been funded and produced by Recordati. All images have been provided by an international
panel of expert pathologists.
The concept, functionality and expert guidance found within this tool has
also
been developed with the support of expert pathologists.
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Regressed GCs: Grade 3
This H&E section of a cervical lymph node shows small atrophic germinal centers with depletion of centrocytes and centroblasts. This is a feature of chronic immune stimulation as seen in chronic viral infections, auto-inflammatory disorders, but also of iMCD.
Abbreviations
GCs, germinal centres; H&E, hematoxylin and eosin; iMCD, idiopathic Multicentric Castleman Disease.
This tool has been funded and produced by Recordati. All images have been provided by an international panel of expert pathologists. The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.
EXPERT GUIDANCE
Regressed GCs: Grade 1
This H&E section of a cervical lymph node shows a conserved compartimentalization between B- and T-cell areas. The large majority of the follicles show normal size and composition.
Abbreviations
GCs, germinal centres; H&E, hematoxylin and eosin.
This tool has been funded and produced by Recordati. All images have been provided by an international panel of expert pathologists. The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.
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